The incidence of type 1 diabetes is increasing [ 1 ]. Concurrently, the prevalence of Caesarean section deliveries has increased and there is an association with the incidence rate of type 1 diabetes [ 2 ]. A meta-analysis revealed a 20% increase …
verfasst von:
Tarini Singh, Andreas Weiss, Kendra Vehik, Jeffrey Krischer, Marian Rewers, Jorma Toppari, Åke Lernmark, William Hagopian, Beena Akolkar, Ezio Bonifacio, Anette-G. Ziegler, Christiane Winkler, TEDDY Study Group
The prevalence of early-onset type 2 diabetes mellitus has increased rapidly worldwide, particularly in Asia, characterised by an impairment of insulin secretion, but the causative genes remain unclear [ 1 – 5 ]. The genes encoding transcription …
verfasst von:
Juan Zhang, Rong Zhang, Chanwei Liu, Xiaoxu Ge, Ying Wang, Fusong Jiang, Langen Zhuang, Tiantian Li, Qihan Zhu, Yanyan Jiang, Yating Chen, Ming Lu, Yanzhong Wang, Meisheng Jiang, Yanjun Liu, Limei Liu
In type 2 diabetes, pancreatic beta cells initially compensate for peripheral insulin resistance by adapting their function and mass to secrete more insulin and retain normoglycaemia [ 1 , 2 ]. Evidence for a predominant role of beta cell …
Indirect data suggest beta cells might be polarised, with evidence of polar distribution of viral particles [ 1 ], insulin granules [ 2 ] and the Golgi apparatus [ 3 ]. More recently, a regulator of cell polarity, liver kinase B1 (LKB1), was shown …
verfasst von:
Dillon Jevon, Louise Cottle, Nicole Hallahan, Richard Harwood, Jaswinder S. Samra, Anthony J. Gill, Thomas Loudovaris, Helen E. Thomas, Peter Thorn
Activation of the hypoxia-inducible factor (HIF) pathway regulates cellular adaptation to hypoxia by affecting the expression of hundreds of target genes [ 1 , 2 ]. This transcriptional response involves genes in various pathways such as those …
verfasst von:
Selina Mäkinen, Sreesha Sree, Tuulia Ala-Nisula, Henric Kultalahti, Peppi Koivunen, Heikki A. Koistinen
In type 1 diabetes, the insulin-producing beta cells of the pancreas are destroyed through the activity of autoreactive T cells. In addition to strong and well-documented HLA class II risk haplotypes, type 1 diabetes is associated with noncoding …
verfasst von:
Jason Groegler, Aïsha Callebaut, Eddie A. James, Thomas Delong
Diabetes mellitus is a heterogeneous disease. Thus, there is currently growing interest in exploiting analytical techniques, particularly unsupervised machine learning, to identify subtypes of patients within those with diabetes that could be the …
verfasst von:
Benedetta Salvatori, Silke Wegener, Grammata Kotzaeridi, Annika Herding, Florian Eppel, Iris Dressler-Steinbach, Wolfgang Henrich, Agnese Piersanti, Micaela Morettini, Andrea Tura, Christian S. Göbl
Hypoglycaemia is an acute complication of diabetes management that may occur as a consequence of insulin or insulin secretagogue therapy [ 1 ]. The negative consequences (physical, psychological and behavioural) of hypoglycaemia are a constant …
verfasst von:
Joseph Mellor, Dmitry Kuznetsov, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Stephanie A. Amiel, Mark Ibberson, Stuart McGurnaghan, Luke Blackbourn, William Berthon, Adel Salem, Yongming Qu, Rory J. McCrimmon, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Joanna Leaviss, Paul M. McKeigue, Helen M. Colhoun
The DCCT demonstrated that high HbA 1c levels are associated with an increased risk of developing chronic complications, such as diabetic retinopathy, diabetic nephropathy, diabetic autonomic neuropathy, diabetic peripheral neuropathy (DPN) and …
verfasst von:
Jolien De Meulemeester, Sara Charleer, Margaretha M. Visser, Christophe De Block, Chantal Mathieu, Pieter Gillard
Over the past 25 years, the knowledge about type 1 diabetes has rapidly expanded leading to progress in clinical disease management, including continuous glucose monitoring (CGM), insulin pumps and hybrid closed-loop insulin systems (HCLs).
verfasst von:
Guy Fagherazzi, Gloria A. Aguayo, Lu Zhang, Hélène Hanaire, Sylvie Picard, Laura Sablone, Bruno Vergès, Naïma Hamamouche, Bruno Detournay, Michael Joubert, Brigitte Delemer, Isabelle Guilhem, Anne Vambergue, Pierre Gourdy, Samy Hadjadj, Fritz-Line Velayoudom, Bruno Guerci, Etienne Larger, Nathalie Jeandidier, Jean-François Gautier, Eric Renard, Louis Potier, Pierre-Yves Benhamou, Agnès Sola, Lyse Bordier, Elise Bismuth, Gaëtan Prévost, Laurence Kessler, Emmanuel Cosson, Jean-Pierre Riveline, on behalf of the SFDT1 study team
CVD remains the leading cause of morbidity and mortality in individuals with type 2 diabetes [ 1 ]. In the SCORE2-Diabetes algorithm [ 2 ], the main predictors of 10-year CVD risk in people with type 2 diabetes are established CVD risk factors …
verfasst von:
Aleksander L. Hansen, Charlotte Brøns, Leonie M. Engelhard, Mette K. Andersen, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Højlund, Niels Jessen, Michael H. Olsen, Henrik T. Sørensen, Reimar W. Thomsen, Allan Vaag
Hypoglycaemia impacts the health and wellbeing of people with diabetes [ 1 – 3 ], which can be subjectively quantified using patient-reported outcome measures (PROMs). Valid and reliable PROMs are vital for accurately assessing real-life health …
verfasst von:
Jill Carlton, Philip A. Powell, Melanie Broadley, Bastiaan E. de Galan, Simon Heller, Jonathan Comins, Myriam Rosilio, Frans Pouwer, Mari-Anne Gall, Christopher J. Child, Rory J. McCrimmon, Donna Rowen
Type 2 diabetes is the third leading cause of death in Puerto Rico, accounting for approximately 10% of deaths [ 1 ]. In the rapidly ageing Puerto Rican population, 20% of adults have been diagnosed with type 2 diabetes [ 2 ]. Puerto Rican adults …
verfasst von:
Danielle E. Haslam, Liming Liang, Kai Guo, Marijulie Martínez-Lozano, Cynthia M. Pérez, Chih-Hao Lee, Evangelia Morou-Bermudez, Clary Clish, David T. W. Wong, JoAnn E. Manson, Frank B. Hu, Meir J. Stampfer, Kaumudi Joshipura, Shilpa N. Bhupathiraju
Coeliac disease is an immune-mediated disease characterised by small intestinal inflammation and villous atrophy [ 1 ]. Coeliac disease has been linked to a wide range of disorders and comorbidities including type 1 diabetes [ 2 ], thyroid disease …
verfasst von:
Shuai Yuan, Dan Leffler, Benjamin Lebwohl, Peter H. R. Green, Jiangwei Sun, Sofia Carlsson, Susanna C. Larsson, Jonas F. Ludvigsson
Already, 31.6 million people are estimated to have diabetes in the EU (Fig. 1 ). Partly due to population ageing, rising prevalence of obesity and societal changes, that figure is set to rise to 33.2 million by 2030. Lack of timely diagnosis and …
verfasst von:
Stefano Del Prato, Bart Torbeyns, Chantal Mathieu, on behalf of the European Diabetes Forum Board
Skeletal fragility is an increasingly recognised, but poorly understood, complication of both type 1 and type 2 diabetes. Fracture risk varies according to skeletal site and diabetes-related characteristics. Post-fracture outcomes, including …
verfasst von:
Angela Sheu, Christopher P. White, Jacqueline R. Center
Diabetes is a metabolic disorder characterised by the inability of pancreatic beta cells to control blood glucose levels. The aetiology of the most common form, type 2 diabetes, is heterogeneous, although population genetic studies have identified …
verfasst von:
Hazem Ibrahim, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Oleg Dyachok, Per-Eric Lund, Muhmmad Omar-Hmeadi, Jouni Kvist, Om P. Dwivedi, Väinö Lithovius, Tom Barsby, Vikash Chandra, Solja Eurola, Jarkko Ustinov, Tiinamaija Tuomi, Päivi J. Miettinen, Sebastian Barg, Anders Tengholm, Timo Otonkoski
