European Journal of Epidemiology OnlineFirst articles

31.05.2024 | METHODS

Use of the instrumental inequalities in simulated mendelian randomization analyses with coarsened exposures

Mendelian randomization (MR) requires strong unverifiable assumptions to estimate causal effects. However, for categorical exposures, the MR assumptions can be falsified using a method known as the instrumental inequalities. To apply the …

verfasst von:: Elizabeth W Diemer, Joy Shi, Miguel A Hernan, Sonja A Swanson

Open Access 31.05.2024 | CANCER

Trends in incidence and mortality of early-onset cancer in Germany between 1999 and 2019

Evidence on the recent temporal trend in the incidence and mortality of early-onset cancer, i.e., cancer diagnosed at ages of < 50 years, in Germany is scarce. To estimate the temporal trend in the incidence and mortality of early-onset cancer in …

verfasst von:: Dina Voeltz, Kira Baginski, Claudia Hornberg, Annika Hoyer

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Open Access 30.05.2024 | NEURO-EPIDEMIOLOGY

Assessing the validity of a Parkinson’s care evaluation: the PRIME-NL study

Parkinson’s disease (PD) is a neurodegenerative progressive and chronic syndrome affecting roughly 6.1 million people globally [ 1 ]. The clinical presentation and progression is highly heterogeneous, whilst current models of care insufficiently …

verfasst von:: Liza M. Y. Gelissen, Robin van den Bergh, Amir H. Talebi, Angelika D. Geerlings, Bart R. Maas, Myrthe M. Burgler, Yvet Kroeze, Agnes Smink, Bastiaan R. Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh

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Open Access 28.05.2024 | REPRODUCTIVE EPIDEMIOLOGY

Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts

While its etiology is not fully elucidated, preterm birth represents a major public health concern as it is the leading cause of child mortality and morbidity. Stress is one of the most common perinatal conditions and may increase the risk of …

verfasst von:: Julie Bergeron, Demetris Avraam, Lucinda Calas, William Fraser, Jennifer R. Harris, Barbara Heude, Piush Mandhane, Theo J. Moraes, Gina Muckle, Johanna Nader, Jean R. Séguin, Elinor Simons, Padmaja Subbarao, Morris A. Swertz, Suzanne Tough, Stuart E. Turvey, Isabel Fortier, Naja Hulvej Rod, Anne-Marie Nybo Andersen

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Open Access 28.05.2024 | NUTRITIONAL EPIDEMIOLOGY

Source-specific nitrate intake and all-cause mortality in the Danish Diet, Cancer, and Health Study

Nitrate and nitrite, often debated dietary components, play multifaceted roles in human health [ 1 ]. Nitrate is a naturally occurring compound formed in living and decaying plants and animals [ 2 ]. Nitrate (NO 3 _-) can be reduced to nitrite (NO …

verfasst von:: Nicola P. Bondonno, Pratik Pokharel, Catherine P. Bondonno, Dorit W. Erichsen, Liezhou Zhong, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Frederik Dalgaard, Lauren C. Blekkenhorst, Ole Raaschou-Nielsen, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Anja Olsen

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Open Access 25.05.2024 | ESSAY

Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol

Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random allocation of genetic variants at conception to estimate the causal linear effect of an exposure on an outcome. Extensions to …

verfasst von:: Fergus W. Hamilton, David A. Hughes, Wes Spiller, Kate Tilling, George Davey Smith

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25.05.2024 | COMMENTARY

Towards more reliable non-linear mendelian randomization investigations

verfasst von:: Stephen Burgess

Open Access 21.05.2024 | NEURO-EPIDEMIOLOGY

Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults

Neurofilament light chain (NfL) is a neuron-specific structural protein released into the extracellular space, including body fluids, upon neuroaxonal damage. Despite evidence of a link in neurological disorders, few studies have examined the …

verfasst von:: May A. Beydoun, Nicole Noren Hooten, Michael F. Georgescu, Hind A. Beydoun, Shaker M. Eid, Marie T. Fanelli-Kuczmarski, Michele K. Evans, Alan B. Zonderman

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10.05.2024 | METHODS

Learning about treatment effects in a new target population under transportability assumptions for relative effect measures

Investigators often believe that relative effect measures conditional on covariates, such as risk ratios and mean ratios, are “transportable” across populations. Here, we examine the identification of causal effects in a target population using an …

verfasst von:: Issa J. Dahabreh, Sarah E. Robertson, Jon A. Steingrimsson

Open Access 06.05.2024 | Correction

Correction: Impact of organised colorectal cancer screening on age-specific population incidences: evidence from a quasi-experimental study in Sweden

In Table 2 of this article, the footnote was missing and should have read ‘Over the period 2003–2006, data on colon cancers have been complemented from the Cancer Registry due to lack of registration of colon cancers in the Swedish Colorectal …

verfasst von:: Gabriella Chauca Strand, Ulf Strömberg, Anna Forsberg, Carl Bonander

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04.05.2024 | METABOLOMIC EPIDEMIOLOGY

Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts

There is growing interest in incorporating metabolomics into public health practice. However, Black women are under-represented in many metabolomics studies. If metabolomic profiles differ between Black and White women, this under-representation …

verfasst von:: Emma E. McGee, Oana A. Zeleznik, Raji Balasubramanian, Jie Hu, Bernard A. Rosner, Jean Wactawski-Wende, Clary B. Clish, Julian Avila-Pacheco, Walter C. Willett, Kathryn M. Rexrode, Rulla M. Tamimi, A. Heather Eliassen

04.05.2024 | COHORT PROFILE

The Chinese keratoconus (CKC) cohort study

The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese population involving a clinical database and biobanks. This ongoing study focuses on the prevention of KC progression and is the …

verfasst von:: Kaili Yang, Xiaotian Liu, Liyan Xu, Yuwei Gu, Qi Fan, Shanshan Yin, Yifan Wang, Yi Yuan, Anqi Chang, Yonghao Zang, Chenchen Yin, Chenjiu Pang, Chongjian Wang, Shengwei Ren

27.04.2024 | REPRODUCTIVE EPIDEMIOLOGY

A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had …

verfasst von:: Julie Boudet-Berquier, Christophe Demattei, Laurence Guldner, Anne Gallay, Sylvie Manouvrier, Jérémie Botton, Claire Philippat, Fleur Delva, Juliette Bloch, Caroline Semaille, Sylvie Odent, Isabelle Perthus, Hanitra Randrianaivo, Sylvie Babajko, Tiphaine Barjat, Claire Beneteau, Naima Brennetot, Ester Garne, Georges Haddad, Mounia Hocine, Isabelle Lacroix, Klervi Leuraud, Michel Mench, Joan Morris, Sophie Patrier, Arnaud Sartelet, Alain Verloes, Christophe Bonaldi, Mélina Le Barbier, Bertrand Gagnière, Philippe Pépin, Ronan Ollivier, Monique Bitoun, Lisa King, Andrea Guajardo-Villar, Eugenia Gomes, Jean-Claude Desenclos, Nolwenn Regnault, Alexandra Benachi

Open Access 23.04.2024 | COVID-19

Continued decline in the incidence of myocardial infarction beyond the COVID-19 pandemic: a nationwide study of the Swedish population aged 60 and older during 2015–2022

The number of myocardial infarctions declined during the early COVID-19 pandemic but mechanisms behind these declines are poorly understood. COVID-19 infection is also associated with an increased risk of myocardial infarction which could lead to …

verfasst von:: Anna C. Meyer, Marcus Ebeling, Enrique Acosta, Karin Modig

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Open Access 20.04.2024 | Screening

The underestimated preventive effects of flexible sigmoidoscopy screening: re-analysis and meta-analysis of randomized trials

Flexible sigmoidoscopy (FS), which is less invasive, resource intensive and costly than colonoscopy, is among the recommended screening options for colorectal cancer (CRC). Four large randomized trials consistently reported statistically …

verfasst von:: Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister

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Open Access 18.04.2024 | Correction

Correction: Agricultural activities and risk of Alzheimer’s disease: the TRACTOR project, a nationwide retrospective cohort study

verfasst von:: Pascal Petit, Elise Gondard, Gérald Gandon, Olivier Moreaud, Mathilde Sauvée, Vincent Bonneterre

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16.04.2024 | COHORT PROFILE

Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection

There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipients with …

verfasst von:: Valentin Goutaudier, Marta Sablik, Maud Racapé, Olivia Rousseau, Benoit Audry, Nassim Kamar, Marc Raynaud, Olivier Aubert, Béatrice Charreau, Emmanuelle Papuchon, Richard Danger, Laurence Letertre, Lionel Couzi, Emmanuel Morelon, Moglie Le Quintrec, Jean-Luc Taupin, Eric Vicaut, Christophe Legendre, Hoa Le Mai, Vishnu Potluri, Thi-Van-Ha Nguyen, Marie-Eliane Azoury, Alice Pinheiro, Georges Nouadje, Pierre Sonigo, Dany Anglicheau, Ineke Tieken, Serge Vogelaar, Christian Jacquelinet, Peter Reese, Pierre-Antoine Gourraud, Sophie Brouard, Carmen Lefaucheur, Alexandre Loupy, the KTD-Innov Consortium

09.04.2024 | COVID-19

Congenital anomalies during Covid-19: artifact of surveillance or a real TORCH?

Infections in the first trimester of pregnancy can be teratogenic, but the possibility that Covid-19 could lead to birth defects is unclear. We examined whether SARS-CoV-2 infection during pregnancy or exposure to pandemic conditions were …

verfasst von:: Nathalie Auger, Laura Arbour, Antoine Lewin, Émilie Brousseau, Jessica Healy-Profitós, Thuy Mai Luu

Open Access 06.04.2024 | AGING EPIDEMIOLOGY

The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data

Aging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for …

verfasst von:: Marije Sluiskes, Jelle Goeman, Marian Beekman, Eline Slagboom, Erik van den Akker, Hein Putter, Mar Rodríguez-Girondo

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Open Access 31.03.2024 | DIABETES MELLITUS

Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility

Cigarette smokers are at increased risk of developing type 2 diabetes: Observational studies show a 20-60% elevated risk in smokers [ 1 , 2 ], and Mendelian randomization (MR) studies support a causal relationship [ 3 ]. Smokers differ from …

verfasst von:: Yuxia Wei, Sara Hägg, Jonathan K. L. Mak, Tiinamaija Tuomi, Yiqiang Zhan, Sofia Carlsson

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